Three reactions in glycolysis operate far from equilibrium and are potential sites for major flux control. List the three enzymes and discuss why each enzyme is or is not the major control site of glycolysis.Hexokinase catalyzes the first exergonic step of glycolysis. However, when the source of glucose-6-phosphate is from glycogen in skeletal muscle, rather than free glucose, the hexokinase reaction is not required. Pyruvate kinase catalyzes the last reaction of glycolysis and is therefore not a good candidate for regulation of the entire pathway. Phosphofructokinase catalyzes a very exergonic reaction at Step 3. This is near the beginning of the pathway, but after the entry of glucose-6-phosphate from glycogen, so it can regulate the entire pathway.

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09-12-2022
Biology

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Three reactions in glycolysis operate far from equilibrium and are potential sites for major flux control. List the three enzymes and discuss why each enzyme is or is not the major control site of glycolysis.Hexokinase catalyzes the first exergonic step of glycolysis. However, when the source of glucose-6-phosphate is from glycogen in skeletal muscle, rather than free glucose, the hexokinase reaction is not required. Pyruvate kinase catalyzes the last reaction of glycolysis and is therefore not a good candidate for regulation of the entire pathway. Phosphofructokinase catalyzes a very exergonic reaction at Step 3. This is near the beginning of the pathway, but after the entry of glucose-6-phosphate from glycogen, so it can regulate the entire pathway.

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bharathparasad577 bharathparasad577 · Answer 1 · 2022-12-17T09:01:28-05:00

Hexokinases, phosphofructokinase-1, and pyruvate kinase, three enzymes that all catalyse irreversible processes, control glycolysis. In reaction to circumstances both inside and outside the cell, the glycolytic pathway's flow is modified.

Hexokinase catalyses the glycolysis process' initial exergonic step. The hexokinase reaction is not necessary, though, when the source of the glucose-6-phosphate is skeletal muscle glycogen as opposed to free glucose. Pyruvate kinase catalyses the final step in glycolysis, making it an unsuitable option to control the complete system. In Step 3, phosphofructokinase catalyses a highly exergonic reaction. This is after the entry of glucose-6-phosphate from glycogen but close to the beginning of the process, thus it can control the entire pathway.

So, the three enzymes are hexokinase, pyruvate kinase, and phosphofructokinase.

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