ar is the signal in prostate development and prostate cancer that has attracted the most investigation. ar is known to serve as a nuclear receptor and belongs to the steroid hormone receptor superfamily. however, it can only reach the nucleus to initiate a signaling cascade once it has been bound to androgen ligands, at which point it may perform its role as a transcription factor

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06-12-2022
Biology

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ar is the signal in prostate development and prostate cancer that has attracted the most investigation. ar is known to serve as a nuclear receptor and belongs to the steroid hormone receptor superfamily. however, it can only reach the nucleus to initiate a signaling cascade once it has been bound to androgen ligands, at which point it may perform its role as a transcription factor

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RupaBera RupaBera · Answer 1 · 2022-12-11T01:49:35-05:00

The progression of prostate cancer to androgen castration levels is made possible by AR overexpression. CRPC can develop in prostate cancer cells that have AR amplification when androgen deprivation therapy is used.

An androgen receptor belongs to what class of receptors?

The androgen receptor (AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a specific kind of nuclear receptor that is activated by binding to androgenic hormones such as testosterone and dihydrotestosterone in the cytoplasm and then translocating into the nucleus.

Why does AR signaling occur?

Castration-resistant prostate cancer (CRPC), a deadly, drug-resistant type of the illness that develops when androgen restriction therapy fails, is caused by the androgen receptor (AR) signaling axis (ADT).

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