DNA polymerase ensures that the correct nucleotide is incorporated into the growing strand of DNA by:
-monitoring the ability of the incoming nucleotide to form the appropriate base pair
-specifically allowing only the correct nucleotide to enter the active site
-selecting the correct nucleotide in a exonuclease active site in the DNA polymerase
-incormorating random nucleotides and then subsequently removing wrong ones
monitoring the ability of the incoming nucleotide to form the appropriate base pair

Question

16-12-2022
Biology

Answered

DNA polymerase ensures that the correct nucleotide is incorporated into the growing strand of DNA by:
-monitoring the ability of the incoming nucleotide to form the appropriate base pair
-specifically allowing only the correct nucleotide to enter the active site
-selecting the correct nucleotide in a exonuclease active site in the DNA polymerase
-incormorating random nucleotides and then subsequently removing wrong ones
monitoring the ability of the incoming nucleotide to form the appropriate base pair

Answer :

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e18554534 e18554534 · Answer 1 · 2022-12-20T06:37:57-05:00

The information is correct.

DNA polymerases help ensure the fidelity of DNA replication by monitoring the ability of incoming nucleotides to form proper base pairs with the template strand. This enzyme uses the base-pairing rules of DNA (A and T, C and G) to ensure that the correct nucleotides are incorporated into the growing DNA strand.

In addition to monitoring base pairs, DNA polymerases use their exonuclease activity to proofread newly synthesized DNA strands and remove mis incorporated nucleotides. This ensures the accuracy of DNA replication.

For this purpose, DNA polymerases have specific sites on their surface, called active sites, to which incoming nucleotides are added. Because the shape of the active site is complementary to the shape of the added nucleotides, the enzyme distinguishes between different nucleotides and ensures that only the correct ones are incorporated into the growing DNA strand.

In addition to their role in DNA synthesis, DNA polymerases also have exonuclease activity, allowing them to proofread newly synthesized DNA strands and remove erroneously incorporated nucleotides. This ensures the accuracy of DNA replication and avoids errors that can lead to mutations.

Overall, DNA polymerases play an important role in ensuring the accuracy of DNA replication and avoiding errors that can lead to mutations.