After binding to the endometrium, trophoblasts develop into two distinct layers, an inner layer of mononuclear cytotrophoblasts and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblasts, which form the early fetal-maternal interface (placenta)
Trophoblast cells and extraembryonic somatic mesoderm develop into the chorion, a membrane that encloses the chorionic cavity. The connecting stalk connects the embryo and yolk sac to the chorion and suspends them in the chorionic sac.
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