Answer :
The water-soluble hormone has characteristics: receptor located on the plasma membrane and initiates pathways that involve second messengers. While lipid- soluble hormones have characteristics are: function as transcriptional activators or inhibitors and can influence multiple genes in a cell receptor located in the cytosol and nucleus.
Hormones that are water-soluble are amines and proteins that actively flow through the cell membrane. The target cell membrane's extracellular surface is where the receptors for each type of water-soluble hormone are expressed.
Lipid-derived (soluble) hormones can enter the cell by passing through the plasma membrane, binding to DNA, and changing the activities of the cell by encouraging the creation of proteins that have an overall impact on the cell's long-term structure and function.
Lipid-soluble hormones enter the target cell and diffuse through the plasma membrane where they bind to a receptor protein. Water-soluble hormones attach to a protein receptor on the cell's plasma membrane.
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