Different proteins that are encoded by various genes govern cell cycle checkpoints. They play a crucial role in cell cycle regulation and halt the cell cycle right away if they notice any issues with the cell, such as mutations.
If the issue is not resolved, the cell cycle will not proceed, and cell death will take place. Cell death prevents cancer by stopping the mutation from spreading into new cells.
Thus, if a mutation develops in a gene that controls a cell cycle checkpoint, the modified gene will pass in new cells, and because there are no checkpoints, the mutated cells will expand uncontrollably. As a result, the individual will likely get cancer at some time in their lives.
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