Answer :
In the movement of small molecules across a lipid bilayer the permeability coefficient can be correlated with the solubility of the molecule in a nonpolar solvent.
Non-polar molecules dissolve in the phospholipid region of the cell membrane and pass without the need for additional protein transporters. Small hydrophobic molecules and gases such as oxygen and carbon dioxide pass quickly through the membrane. Small polar molecules like water and ethanol can also pass through the membrane, but more slowly.
A conformational change in the channel moves the second-site potassium ion away from the protein. When a second potassium ion binds to the first site, electrostatic repulsion occurs and helps dislodge the potassium ion from the second site. Permeability decreases with charged or larger molecules. The structural features of these molecules do not affect membrane fluidity. Expression of permeability of molecules across membranes based on molecular size and charge.
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