a patient has a hypercellular bone marrow and is suspected of having a myeloproliferative disorder. laboratory features include: excess megakaryocyte proliferation and atypia, marked marrow fibrosis, and the jak2 mutation. the most likely diagnosis is:

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20-12-2022
Biology

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a patient has a hypercellular bone marrow and is suspected of having a myeloproliferative disorder. laboratory features include: excess megakaryocyte proliferation and atypia, marked marrow fibrosis, and the jak2 mutation. the most likely diagnosis is:

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Riya99 Riya99 · Answer 1 · 2022-12-21T15:26:00-05:00

Jak2 mutation, pronounced marrow fibrosis, and excessive megakaryocyte proliferation and atypia. Hypercellular bone marrow is the most likely diagnosis.

What causes hypercellular bone marrow in MDS?

Background: In order to make up for inefficient hematopoiesis, myelodysplastic syndrome (MDS) patients' bone marrow (BM) is typically hypercellular. According to the disease's heterogeneity, a subset of MDS patients have normo- or hypocellular BM.

What causes iron deficient anemia to have hypercellular bone marrow?

These results imply that the hypercellularity of the bone marrow in an iron shortage state may be due to the stalling and sequester of erythroid precursors inside the marrow rather than a compensatory mechanism of enhanced cell proliferation. It also undergoes biochemical modifications.

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