Answer :
DNA ligase is used less for leading strand replication than for lagging strand replication.
The isolated DNA strands form a replication fork in which both DNA strands replicate, resulting in a lagging and leading strand. The primary distinction between a lagging and a leading strand is that the lagging strand reproduces infrequently, having formed short fragments, meanwhile the leading strand replicates constantly.
As the helix unwinds, DNA synthesis on the lagging strand reboots numerous times, culminating in many short fragments known as "Okazaki fragments." The Okazaki fragments are joined together to form a single DNA molecule by DNA ligase.
By joining interruptions in the phosphodiester backbone of DNA that arises during replication and recombination, as well as as a result of DNA damage and repair, DNA ligases play an important role in maintaining genomic integrity.
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