which krebs cycle intermediate can move from the mitochondria into the cytoplasm to become the initiator of fatty acid synthesis

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19-12-2022
Biology

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which krebs cycle intermediate can move from the mitochondria into the cytoplasm to become the initiator of fatty acid synthesis

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jaiswaljyoti jaiswaljyoti · Answer 1 · 2022-12-23T01:59:09-05:00

Citrate can move from the mitochondria into the cytosol, where citrate lyase cleaves it into oxaloacetate and acetyl-CoA, the ini- tiator of fatty acid synthesis.

Citrate is produced within the Krebs cycle from oxaloacetate and acetyl-CoA by citrate synthase (CS). it can be exported from the mitochondria through citrate carrier (CIC). Cytosolic citrate is broken down by ACLY to oxaloacetate and acetyl-CoA. Acetyl-CoA may be used as a substrate for fatty acid synthesis.

as an example, citrate, a TCA cycle intermediate, can pass across the mitochondrial membrane to the cytosol, in which it's far cleaved into OAA and acetyl CoA to aid a selection of biosynthetic methods, which include the synthesis of fatty acid and sterols.

Krebs cycle intermediates (KCIs) are said to feature as strength substrates in mitochondria and to exert antioxidants effects at the brain. the existing examine was designed to perceive which KCIs are powerful neuroprotective compounds in opposition to oxidative pressure in neuronal cells.

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