what is the target of the mediator kinase cdk8 (srb10)?

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19-12-2022
Biology

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what is the target of the mediator kinase cdk8 (srb10)?

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akursharma9034 akursharma9034 · Answer 1 · 2022-12-23T13:55:45-05:00

Cyclin H is the target of the mediator kinase cdk8 (srb10).

The activities of the cell cycle are regulated by cyclins working with the cyclin-dependent kinases enzyme family (Cdks). A Cdk that is not bound to a cyclin is inactive, but when it is, it becomes a functioning enzyme that can alter target proteins.

Nuclear serine-threonine kinase CDK8 controls transcription by acting as a kinase. Since just a small portion of CDK8 is linked with Mediator in cells, roles outside of this complex are also plausible. However, the majority of what is known about CDK8 comes from its facultative interaction with the Mediator complex.