An intron in the 5′UTR may improve gene expression by including transcriptional regulatory elements or by structural manipulation and splicing. The presence of an intron in the 5′UTR, for example, is required for the production of the ubiquitin C (UbC) gene.
The eukaryotic 5' untranslated region (UTR) is important for ribosome binding to mRNA and start codon selection, as well as for controlling translation efficiency and structuring the cellular proteome.
Untranslated regions (UTRs) of transcripts are important regulators of gene expression in higher eukaryotes (influencing mRNA stability and translation efficiency).
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