the ___ dopamine pathway plays an important role in the reinforcing and addictive properties of drugs like nicotine

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16-12-2022
Biology

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the ___ dopamine pathway plays an important role in the reinforcing and addictive properties of drugs like nicotine

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contexto1005 contexto1005 · Answer 1 · 2022-12-20T13:03:40-05:00

The mesolimbic dopamine pathway plays an important role in the reinforcing and addictive properties of drugs like nicotine. This pathway is a collection of neurons located in the brain stem and extending to the ventral tegmental area (VTA).

The reinforcing and addictive properties of nicotine are primarily due to its ability to activate the mesolimbic dopamine pathway. When nicotine is consumed, it enters the bloodstream and is transported to the brain where it binds to nicotinic acetylcholine receptors. This binding increases the activity of the neurons in the VTA and they release dopamine into the nucleus accumbens, resulting in feelings of reward and pleasure. Over time, the brain becomes conditioned to expect the reward associated with nicotine and this reinforces the desire to consume more nicotine.

The mesolimbic dopamine pathway is also involved in the development of addiction to nicotine. When nicotine is repeatedly consumed, the brain adapts and becomes desensitized to the dopamine-releasing effects of nicotine. This means that the individual needs to consume more nicotine to experience the same reward and pleasure that they did when they first started. This can lead to increased nicotine consumption over time, resulting in an addiction to nicotine.

Learn more about ventral tegmental area (VTA) at :https://brainly.com/question/26478934

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