A 30-year-old woman complains of recent easy fatigability, bruising, and recurrent throat infections. Physical examination reveals numerous petechiae over her body and mouth. Abnormal laboratory findings include hemoglobin of 6 g/dL, WBC of 1,500/mL, and platelets of 20,000/mL. The bone marrow is hypocellular and displays increased fat. What is the appropriate diagnosis?(A) Aplastic anemia(B) Iron-deficiency anemia(C) Megaloblastic anemia(D) Myelofibrosis with myeloid metaplasia(E) Pure red cell aplasia

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16-12-2022
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A 30-year-old woman complains of recent easy fatigability, bruising, and recurrent throat infections. Physical examination reveals numerous petechiae over her body and mouth. Abnormal laboratory findings include hemoglobin of 6 g/dL, WBC of 1,500/mL, and platelets of 20,000/mL. The bone marrow is hypocellular and displays increased fat. What is the appropriate diagnosis?(A) Aplastic anemia(B) Iron-deficiency anemia(C) Megaloblastic anemia(D) Myelofibrosis with myeloid metaplasia(E) Pure red cell aplasia

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sohamnaik sohamnaik · Answer 1 · 2022-12-19T22:07:09-05:00

The answer to the question is (A) Aplastic anemia.

Aplastic anemia is a malignancy in which the body produces insufficient amounts of blood cells. The stem cells that live in the bone marrow create blood cells. Red blood cells, white blood cells, and platelets are all deficient as a result of aplastic anaemia.

Although it happens commonly among the elderly, it happens most frequently in adults in their teens and 20s. Hereditary factors, immunological disorders, exposure to chemicals, medications, or radiation are some of its possible causes. However, there is no recognised aetiology in roughly 50% of instances. A bone marrow biopsy can provide a conclusive diagnosis of aplastic anaemia. In healthy bone marrow, there are between 30 and 70 percent blood stem cells; however, in aplastic anaemia, these cells are largely absent and are replaced by fat.

Immunosuppressive medications, often either anti-lymphocyte globulin or anti-thymocyte globulin, are paired with corticosteroids, chemotherapy, and ciclosporin as the first-line treatment for aplastic anaemia. Additionally, hematopoietic stem cell transplantation is employed, particularly in patients under the age of 30 who have a related, compatible marrow donor. Eleanor Roosevelt and Marie Curie are known to have perished as a result of aplastic anaemia.

To learn more about, refer Aplastic anemia: https://brainly.com/question/28271905

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