A 60-year-old woman complains of weakness and hematuria. Physical examination shows marked pallor, hepatosplenomegaly, and numerous ecchymoses of the upper and lower extremities. A CBC reveals a normocytic normochromic anemia, thrombocytopenia, neutropenia, and a marked leukocytosis, which is composed mainly of myeloblasts. The major clinical problems associated with this patient's condition are most directly related to which of the following?
(A) Avascular necrosis of bone
(B) Disseminated intravascular coagulation
(C) Hypersplenism
(D) Microangiopathic hemolytic anemia
(E) Suppression of hematopoesis



Answer :

The major clinical problems associated with this patient's condition are most directly related to Option E is the correct response: Suppression of hematopoiesis.

In order to create and replenish the blood system, hematopoiesis, or the synthesis of blood cell components, takes place during embryonic development and throughout maturity.

Erythrocytes, platelets, granulocytes, lymphocytes, and monocytes are just a few of the many blood and bone marrow cells that are produced during the process known as hematopoiesis.

Erythropoietin, often known as EPO, is a hormone that signals the bone marrow's hematopoietic (blood-forming) cells to produce hemoglobin. This hormone, which is mostly made by the kidney, responds to a drop in blood oxygen saturation by up to a thousand times higher Epo levels.

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