The probability of having a child that does not express PKU when the women and her husband both are carriers will be 25 %.
PKU is a genetic disease where the levels of phenylketonuria are high in the blood of the affected person. This happens due to the mutation in the phenylalanine hydroxylase (PAH) gene. The gene is responsible for the breakdown of the phenylalanine in the body.
Carriers are the heterozygous individuals that carry one dominant and one recessive allele for the trait. When two heterozygous individuals cross the probability of offspring having homozygous recessive or dominant genotype is 25 % for each. While the probability of obtaining heterozygotes is 50%.
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