Long term potentiation is a persistent increase in synaptic strength following high-frequency stimulation of a chemical synapse.
Associative learning, which is shown in areas of the brain like the hippocampus and cerebral cortex, is thought to have a cellular model in associative LTP.
when LTP-inducing high-frequency stimulation is applied to another independent strong input, a sustained rise in synaptic transmission efficiency is brought about in an input that is active.
While high-frequency stimulation of a weak input (such as 100 Hz for one second) frequently fails to generate long-term potentiation (LTP), the weak input can demonstrate LTP when the strong input is stimulated at the same time (Long-Term Potentiation, Gene expression). Associative LTP is the name for this kind of LTP. LTP is typically not triggered in a weak pathway but rather in an input that is generally quite powerful.
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