which pair of molecules are found in cytotoxic t lymphocyte (ctl) granules and are important for ctl killing of target cells?

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15-12-2022
Biology

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which pair of molecules are found in cytotoxic t lymphocyte (ctl) granules and are important for ctl killing of target cells?

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contexto1019 contexto1019 · Answer 1 · 2022-12-20T18:30:48-05:00

Both perforin and granzymes are essential for the effective and efficient killing of cells. They are found in cytotoxic t lymphocyte granules.

The protein perforin, often referred to as cytoplasmic granule toxins, is a pore-forming agent. The cytotoxic granules of cytotoxic lymphocytes include a family of structurally similar serine proteases known as Granzyme (CLs). Target-cell apoptosis is collaboratively induced by perforin and granzyme. Target cells must be properly supplied by perforin in order for granzyme to cause apoptosis to occur.

Granzyme's likelihood of passive diffusion is further reduced by the fact that both perforin and granzyme attach to the target-cell surface as a single macromolecular complex linked with serglycin. Granzymes A and B's roles in triggering target-cell death have undergone significant in vitro research, and their molecular actions are more known than those of perforin.

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