mycobacterium tuberculosis is taken up by lung macrophages but is not digested. what protects these bacteria in the macrophage so that they can survive and reproduce in the lungs?

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15-12-2022
Biology

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mycobacterium tuberculosis is taken up by lung macrophages but is not digested. what protects these bacteria in the macrophage so that they can survive and reproduce in the lungs?

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arenasaleem890 arenasaleem890 · Answer 1 · 2022-12-21T02:42:46-05:00

Mycobacterium tuberculosis is the bacteria that causes tuberculosis (TB). Although the TB germs typically assault the lungs, they can also affect the kidney, spine, and brain. Not every person who contracts the TB germs gets ill.

Before killing a macrophage, M. tuberculosis cells first group together and "gang up" on it. The macrophage then engulfs the clump and perishes from bacterial overpowering. The germs are not eliminated as a result, and they multiply quickly inside the decomposing macrophage. M. tuberculosis can lay dormant inside the host cells for years while still having the ability to get active. M. tuberculosis can avoid the host's active immune system thanks to its dormancy or latency. The host-pathogen surface of MTB has a specific envelope made of particular lipids, which aids in immune escape [112]. According to Chen et al., phagocyte MTB escapes into the cytoplasm in order to prevent lysosome death.

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