what triggers a b-cell to proliferate and differentiate, and what cell types/functions this creates

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15-12-2022
Biology

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what triggers a b-cell to proliferate and differentiate, and what cell types/functions this creates

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bharathparasad577 bharathparasad577 · Answer 1 · 2022-12-23T01:01:50-05:00

Creation of fully developed immune-competent B cells maturation. Maturity-dependent B-cell activation and differentiation into plasma cells and memory B cells.

B-cell production starts in the embryo and continues throughout life.
Major locations of B cell maturation before birth include the yolk sac, foetal liver, and foetal bone marrow.
Following birth, hematopoietic stem cells in the bone marrow produce mature B-cells (HSC).
The HSC first divide to create lymphoid progenitor cells, and these cells subsequently differentiate and maturation into progenitor B-cells (pro B), which express a transmembrane tyrosine phosphatase known as CD45R and a signalling molecule known as Ig/Ig that is later identified linked with the membrane-bound antibody.
Pro-B cells furthermore exhibit CD19 (part of co-receptor),CD43 (leukosialin), CD24 (heat stable), and C-kit are present on the surface of Pro-B-cell.

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