why is the presence and activity of acetylcholinesterase every bit as important as acetylcholine release in the first place?

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15-12-2022
Biology

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why is the presence and activity of acetylcholinesterase every bit as important as acetylcholine release in the first place?

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rathipushpendra345 rathipushpendra345 · Answer 1 · 2022-12-25T03:25:04-05:00

Organophosphates are acetylcholinesterase inhibitors with the potential for exposure and harm. AChE's main purpose is to prevent ACh by stopping synaptic signalling and neuronal transmission.

Organophosphates are one of the most frequent global causes of poisoning through agricultural, unintentional, or exposure because of their extensive use. Organophosphate exposure can result in symptoms like confusion, headaches, and memory loss, as well as neurotoxic effects after prolonged exposure. Irreversible acetylcholinesterase inhibitors employed in warfare as nerve agents or insecticides are extremely hazardous.

The cholinergic enzyme acetylcholinesterase (AChE), particularly in muscles and nerves, is primarily found at postsynaptic neuromuscular junctions. It instantly converts acetylcholine (ACh), a naturally occurring neurotransmitter, into acetic acid and choline through a process known as hydrolysis.

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