Identify the structures of the nephron that maintain the high solute concentration in the medullary region of the kidney.
Loop of Henle, Vasa recta

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12-12-2022
Biology

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Identify the structures of the nephron that maintain the high solute concentration in the medullary region of the kidney.
Loop of Henle, Vasa recta

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contexto38 contexto38 · Answer 1 · 2022-12-18T08:20:45-05:00

The structures of the nephron that maintain the high solute concentration are Loop of Henle and Vasa recta.

The thin ascending limb is water-impermeable but ion-permeable, allowing for some sodium reabsorption. Because Na/K-ATPase is expressed at extremely low levels in this segment, reabsorption occurs by passive diffusion.

Because of the osmotic pressure caused by the countercurrent system, salt travels out of the tubule and into the interstitium. The ascending limb portions in the medulla and cortex are functionally quite similar.

Water has little access to the medullary ascending limb. Active transport reabsorbed sodium, potassium, and chloride ions. The Na+/K+/Cl co-transporter and the sodium/hydrogen exchanger are the primary active transport mechanisms in this section.

Overall, this section accounts for 25-30% of total Na+ reabsorption along the nephron. This is clinically significant since "loop diuretics" are often used. This active transport allows the kidney to create an osmotic gradient, which is required for the kidney to concentrate urine past isotonicity.

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Identify the structures of the nephron that maintain the high solute concentration in the medullary region of the kidney. Loop of Henle, Vasa recta

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Identify the structures of the nephron that maintain the high solute concentration in the medullary region of the kidney.
Loop of Henle, Vasa recta