Answer :
Antibodies are naturally metabolized or bound to antigen and cleared from circulation.
In germ-free environments, natural antibodies build spontaneously without specific immunization. Although this definition excludes anti-Gal antibodies and/or natural anti-Gal antibodies, they constitute the newborn organism's first line of defence. Prior to the development of germinal centres, in which adaptive antibodies are generated, natural antibodies serve as the initial line of defence against pathogens. Antigen-induced immune responses can be classified as primary or secondary responses. On the initial interaction with an antigen, the main immune response takes place. The resolution of this response, which can last up to 14 days, results in the development of memory cells with a high level of antigen-specificity.
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