leptin is an adipokine, a peptide hormone secreted by adipose tissue. it plays a major role in coordinating response systems linking the nutritional state of the body to environmental signals. for example, if the environment provides enough food, the body will build up fat reserves (triacylglycerols, or tags). the adipocytes release leptin, resulting in inhibition of food intake and increased energy expenditure. in 1949, an obese strain of mice was established that possessed a mutation mapping to mouse chromosome 6. mice that were homozygous for the mutation (ob/ob) were obese. in 1994, jeffrey friedman and colleagues characterized the ob gene and later isolated the product of the gene, a protein of 167 amino acids (designated leptin) that is exclusively produced in adipose tissue. what is the likely reason that ob/ob mice are obese?\

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12-12-2022
Biology

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leptin is an adipokine, a peptide hormone secreted by adipose tissue. it plays a major role in coordinating response systems linking the nutritional state of the body to environmental signals. for example, if the environment provides enough food, the body will build up fat reserves (triacylglycerols, or tags). the adipocytes release leptin, resulting in inhibition of food intake and increased energy expenditure. in 1949, an obese strain of mice was established that possessed a mutation mapping to mouse chromosome 6. mice that were homozygous for the mutation (ob/ob) were obese. in 1994, jeffrey friedman and colleagues characterized the ob gene and later isolated the product of the gene, a protein of 167 amino acids (designated leptin) that is exclusively produced in adipose tissue. what is the likely reason that ob/ob mice are obese?\

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mishrasomvt mishrasomvt · Answer 1 · 2022-12-22T00:33:16-05:00

The likely reason that ob/ob mice are obese is due to a mutation in the ob gene, which leads to a deficiency in the production of the hormone leptin.

What is leptin ?

Leptin plays a major role in coordinating response systems linking the nutritional state of the body to environmental signals. When the body has enough food, the adipose tissue (fat) releases leptin, which inhibits food intake and increases energy expenditure.

In ob/ob mice, there is a deficiency in leptin production, leading to an inability to regulate food intake and energy expenditure properly. This results in an accumulation of fat reserves, leading to obesity.

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