In the general population, 1 in 300 individuals is a carrier for Tay-Sachs disease, while 1 in 30 individuals of Ashkenazi Jew descent are carriers. Tay-Sachs also affects 1 in 30 individuals with French-Canadian ancestry, although two completely unique mutations are responsible for the Ashkenazi and French-Canadian mutations.Part A What are the chances of two individuals having a child with Tay-Sachs if both individuals are not of Ashkenazi or French-Canadian descent? Enter your answer using scientific notation. For the multiplication symbol, use an asterisk ). 2.77×10-8 Submit My Answers Give Up CorrectPart B What are the chances of two individuals having a child with Tay-Sachs if one individual is of Ashkenazi descent and one is not? 2.77*10-5 Submit My Answers Give Up CorrectPart B What are the chances of two individuals having a child with Tay-Sachs if one individual is of Ashkenazi descent and one is not? 2.77*10-5 Submit My Answers Give Up CorrectPart D What are the chances of two individuals having a child with Tay-Sachs if the father is an Ashkenazi carrier and the mother is a French-Canadian carrier?



Answer :

(1/30) × (1/300) × 1/4 = 2.77 × 10⁻⁵,Chance of mom being a carrier × Chance of dad being a carrier × Chance of having an affected child if both parents are carriers), In the general population, 1 in 300 individuals is a carrier for Tay-Sachs disease, while 1 in 30 individuals of Ashkenazi Jew descent are carriers

Tay-Sachs disease is a rare genetic ailment that is inherited from both parents. It is brought on by the lack of an enzyme that aids in the breakdown of fatty materials. These fatty compounds, known as gangliosides, accumulate to toxic amounts in the brain and spinal cord and impair the nerve cells' ability to function. By the age of 3 to 5 years, the illness is typically deadly, frequently as a result of complications from a lung infection (pneumonia). Juvenile Tay-Sachs disease and other uncommon forms of the disease first manifest in early adulthood or later in childhood (late-onset Tay-Sachs disease).

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