Answer :
(1/30) × (1/300) × 1/4 = 2.77 × 10⁻⁵,Chance of mom being a carrier × Chance of dad being a carrier × Chance of having an affected child if both parents are carriers), In the general population, 1 in 300 individuals is a carrier for Tay-Sachs disease, while 1 in 30 individuals of Ashkenazi Jew descent are carriers
Tay-Sachs disease is a rare genetic ailment that is inherited from both parents. It is brought on by the lack of an enzyme that aids in the breakdown of fatty materials. These fatty compounds, known as gangliosides, accumulate to toxic amounts in the brain and spinal cord and impair the nerve cells' ability to function. By the age of 3 to 5 years, the illness is typically deadly, frequently as a result of complications from a lung infection (pneumonia). Juvenile Tay-Sachs disease and other uncommon forms of the disease first manifest in early adulthood or later in childhood (late-onset Tay-Sachs disease).
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