Answer :

Because ligands are particular to their receptors, the secondary messengers and inactive relay proteins that are produced in the cell to start a response are also.

What characteristic blocks the entry of ligands to cell-surface receptors?

The extracellular domain is where the molecules attach. Since the molecules are hydrophilic, they cannot pass through the plasma membrane's hydrophobic interior.

What occurs if the ligand is taken away from the receptor?

Desensitization of the target cell and elimination of the ligand by degradation or sequestration are two methods for receptor deactivation. A ligand's binding to a receptor is reversible because the ligand will eventually separate from the receptor and may be broken down.

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