The bicarbonate ions neutralise the hydronium ions when an acidic material enters the circulation, creating carbonic acid and water. Already, blood's buffering mechanism includes carbonic acid.
Bicarbonate (HCO3-) functions as a buffer against pH fluctuations because it can reversibly bind a free hydrogen ion (Review Buffer Basics). The bicarbonate buffer has a high buffering capacity around the typical ECF pH of 7.4, with a pK of 6.1.
The bicarbonate/carbonic acid buffering mechanism works to "neutralise" excess acid or base while maintaining a typical range of plasma pH. Bicarbonate binds excess hydrogen ions in metabolic acidosis.
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