Answer :
A deletion type of chromosomal mutation will usually have the most detrimental effect on organismal function , because there will be no protein product produced for genes in the affected region.
Therefore, the protein produced by the gene could not work effectively. By deletion at least one nucleotide from a chromosomal mutation , a deletion modifies the DNA sequence. Larger deletions can eliminate a organismal function gene or a number of nearby chromosomal mutation , while smaller deletions just delete one or a few nucleotides from a chromosomal . When there is homologous but uneven organismal function across chromosomal sequences, deletions happen. During mitosis or meiosis mutation , similar sequences in the human genome might cross across, shortening a section of the chromosomal sequence.
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