Supercoiling term describes the tertiary structural organization of chromosomal dna that allows the long strand to be packed and fit into the cytoplasm of the cell
What does supercoiling mean?
- A higher-order DNA structure is described by DNA supercoiling. Two complimentary strands are wound around one another and around a shared helical axis to form the double-helical structure of DNA.
- Supercoiling happens when the molecule twists around itself to release the helical stress. Positive supercoiling results from overtwisting, whereas negative supercoiling results from undertwisting. In a circular model, twist can be changed by severing the circle, over- or undertwisting, and then re-connecting the ends.
- Small intranucleosomal DNA loops arise in conjunction with RNA polymerase II (Pol II) transcription through chromatin. DNA supercoiling builds up when Pol II is trapped inside a tiny loop,
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