T-cell tropic (T-tropic) viruses can infect CD4+ T cells and primary cultures of established T-cell lines, but not primary macrophages is the difference between macrophage-tropic and lymphocyte-tropic HIV strains.
What is macrophages?
- Macrophages are specialized cells involved in recognizing, phagocytosing, and destroying bacteria and other pests.
- In addition, they can cause inflammation by presenting antigens to her T cells and releasing molecules (called cytokines) that activate other cells.
- A type of white blood cell that surrounds and kills microorganisms, removes dead cells, and stimulates the action of other cells of the immune system.
- Macrophages can be classified based on their basic function and activation.
- According to this classification, there are classically activated (M1) macrophages, wound healing macrophages and regulatory macrophages.
- Macrophages are found in many organs of the body, such as the liver, brain, bones, lungs, and blood, especially at sites of infection.
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