Answer :
A mutation that knocked out the proofreading function of dna polymerase would result in become permanently inactive.
How can mutations originate from DNA polymerase?
Despite the very high fidelity with which most DNA replicates, errors can occur from time to time when polymerase enzymes insert the incorrect nucleotide or too many or too few nucleotides into a sequence.
A mutation is the result of that slight deviation from the original DNA sequence. Additionally, exposure to certain chemicals or radiation might result in mutations. The DNA is damaged by these substances. This is not inherently abnormal because DNA deteriorates even in the most remote and pristine locations.
The majority of the replicative polymerases' proofreading activity is in charge of removing incorrectly incorporated nucleotides from the primer terminus prior to further primer extension.
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