A cell has a mutation that results in higher levels of phosphorylated proteins than normal cells without the mutation. What kind of mutation could have occurred and what reasoning leads to this claim?.

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08-11-2022
Biology

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A cell has a mutation that results in higher levels of phosphorylated proteins than normal cells without the mutation. What kind of mutation could have occurred and what reasoning leads to this claim?.

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contexto1212 contexto1212 · Answer 1 · 2022-11-14T09:52:56-05:00

A sensitive and dynamic method of controlling protein activity, stability, protein interaction, and subcellular localization is provided by phosphorylation. Multiple kinases frequently target global regulators, changing the expression of numerous genes.

Kinase mutations can deactivate apoptotic pathways, activate proliferative pathways that disrupt cell cycle checkpoints and lead to genomic instability, inhibit or eliminate DNA damage response, increase angiogenesis and cell motility, or all of the above.Kinase mutations can decrease or abolish the DNA damage response, increase angiogenesis and cell motility, activate proliferative pathways that break cell cycle checkpoints and cause genomic instability, or do all of the above.Hanks-type kinases and phosphatases are used by bacteria for signal transduction, just like eukaryotes, and protein phosphorylation is involved in a variety of cellular processes.

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