What would be the most likely result if a mutation caused tlr5 to always be on, or to always act as if it were bound to flagellin, even in the absence of flagellin?.

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08-11-2022
Biology

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What would be the most likely result if a mutation caused tlr5 to always be on, or to always act as if it were bound to flagellin, even in the absence of flagellin?.

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contexto115 contexto115 · Answer 1 · 2022-11-15T00:41:15-05:00

If TLR5 remains on always or act as if it were bound to flagellin even in the absence of flagellin then this would lead to needless activation of the immune system.

TLRs and NLRs which are short for Todd-like receptors and Nod-like receptors respectively are the watchmen of the immune system and can be regarded as Immune system activators.

TLRs are present in the gut and play a pivotal role in recognizing pathogen associated invasion pattern thereby stimulating the body's immune system for action. The TLRs signal through involvement of particular adaptor molecules thereby leading to activation of transcription factors like Nuclear factor-Kappa B(NF-κB) and IRFs.

Human and other mammals' body consists of many pattern-recognizing receptors which include TLRs, NLRs, ALRs, RLRs etc. The foremost function of PRR is that they identify pathogen associated molecular patters. TLRs were the first ones to be identified and the most studied on pattern recognizing receptor.

To learn more about TLRs visit

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