A mutation that knocked out the proofreading function of dna polymerase would result in __________.

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08-11-2022
Biology

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A mutation that knocked out the proofreading function of dna polymerase would result in __________.

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SamuelSundar SamuelSundar · Answer 1 · 2022-11-14T11:36:08-05:00

A mutation that knocked out the proofreading function of dna polymerase would result in a higher-than-normal rate of DNA synthesis errors. Without this proofreading function, incorrect nucleotides would be inserted about once every 100,000 bases instead of once every 10,000,000 bases.

What is proofreading function of dna polymerase ?

It enables the enzyme to examine each nucleotide as DNA is being synthesised and remove any mismatched ones in the 3' to 5' direction. A polymerase can also remove unpaired 3' overhanging nucleotides to produce blunt ends thanks to the proofreading domain.

DNA polymerase proofreading is crucial for preventing unacceptably high mutation rates brought on by mistakes in nucleotide incorporation and the replication of harmed DNA.

Learn more about Proofreading function here:

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