Genes involved in lactose metabolism can be found in the E. coli lac operon. Only when lactose and glucose are both present does it express.
By hydrolyzing the 1,4 glycosidic link on the lactose disaccharide in E. coli, -D-glucosidase produces -D-glucose and -D-galactose.
When lactose is available in the environment, it binds to the repressor protein and inhibits it from binding to the operator, allowing the transcription of the genes in the lac operon. Repressing the repressor is therefore how the lac operon is activated.
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