A mutation that knocked out the proofreading function of DNA polymerase would result in a higher-than-normal rate of DNA synthesis errors.
DNA synthesis errors would occur more frequently than usual if a mutation rendered DNA polymerase incapable of proofreading.
The polymerase enzyme corrects errors that are frequently made during DNA synthesis or replication. The enzyme double-checks the base sequence to make sure that each time the new, elongating strand is added, the proper nucleotide bases that are complementary to the parent strand are added.
A higher-than-normal error rate will arise at the end of replication if a mutation occurs in the DNA polymerase enzyme and it loses the capacity to check for and correct errors.
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