At G1 cell-cycle checkpoints, external stressors have the greatest effect.
Checkpoints ensure that important steps are followed to ensure that each phase of the cell cycle is carried out correctly. A set of conditions must be met before the cell may advance to the next level in this control mechanism. Checkpoint failure results in cell cycle arrest, which stops the cell from growing until the issues are fixed.
The three major checkpoints in the cell cycle are G1, G2, and M.
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