The nuclease, DNA polymerase, and ligase are the enzymes involved in nucleotide excision repair.
Mammals primarily use nucleotide excision repair (NER) to remove large DNA lesions from DNA, such as those caused by UV light, environmental mutagens, and some cancer chemotherapeutic adducts.
In nucleotide incision repair (NIR), an endonuclease nicks DNA that has been oxidatively damaged in a way that is independent of DNA glycosylase while also repairing the remaining 5'-dangling modified nucleotide.
The base excision repair system recognises small, non-distorting damages in the DNA helix, whereas the nucleotide excision repair system recognises large, DNA helix distorting damages.
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