the mammalian immune system is informed of the presence of pathogens (e.g., infections) by the presence of foreign peptides that are bound and presented by

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helppp4495 helppp4495

08-11-2022
Biology

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the mammalian immune system is informed of the presence of pathogens (e.g., infections) by the presence of foreign peptides that are bound and presented by

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qwbeige qwbeige · Answer 1 · 2022-11-15T06:57:17-05:00

The mammalian immune system is informed of the presence of pathogens (e.g., infections) by the presence of foreign peptides that are bound and presented by class I and class II MHC molecules.

Class I and class II MHC (major histocompatibility complex) proteins are essential components of the adaptive immune system. The task of presenting peptides on the cell surface for recognition by T cells is shared by both classes of proteins.

After a protracted search in secondary lymphatic organs, the persistent engagement between a T cell receptor and particular pMHC complexes eventually causes T cells to multiply and generate a particular cellular immune response. Once processed, each specific MHC allelic variant's binding groove structural characteristics heavily influence the peptide repertoire that MHC proteins present.

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