Answer :
The sodium channels that once initiate an action potential remain inactivated for a brief period after being open due to the absolute refractory period.
In neurons, the absolute refractory period occurs for a fraction of a millisecond to ensure that another action potential does not start immediately. This period occurs due to the inactivation of sodium ion channels that generally opens to depolarise the membrane. After the sodium channel gets back to resting conformation i.e., sodium channels remain inactivated until the membrane is hyperpolarised. Then sodium channel is activated to start a new action potential.
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