Common way in which microbes gain resistance to rifampicin is through a mutation in a gene that encodes a protein involved in transcription.
Transcription is the process of making RNA copy of a gene's DNA sequence. This copy which is called mRNA carries the gene's protein information encoded in DNA.
The process by which DNA is copied to RNA is called transcription whereas that by which RNA is used to produce proteins is called translation.
Transcription is a process in which a gene's DNA sequence is copied to make RNA molecule and RNA polymerase is the main transcription enzyme. Transcription begins when RNA polymerase binds to promoter sequence near the beginning of a gene .
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