If you invented a drug that inhibited topoisomerase in bacterial cells, what would those cells no longer be able to do?.

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04-11-2022
Biology

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If you invented a drug that inhibited topoisomerase in bacterial cells, what would those cells no longer be able to do?.

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ikarikayah ikarikayah · Answer 1 · 2022-11-09T11:22:30-05:00

Then in such cells, there will be a blocker of the ligation step of the cell cycle, which results in the breaking of single and double strands of DNA, which leads to the death of apoptosis cells.

What is a topoisomerase inhibitor?

Topoisomerase I and II are normal host enzymes found in the nucleus of mammalian cells and are required for normal DNA replication and cell division. Enzymes make and then repair single-stranded notches in cellular DNA. The incision allows the unraveling and relaxation of the supercoiled double-stranded DNA so that replication can continue. After the torsional stretch of DNA is removed, the topoisomerase reseals the relaxed double helix. Topoisomerase activity is especially increased in the rapid division and cancer cells. It is an appropriate, but a non-select target for anticancer therapy.

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