The insertion of "foreign" DNA into the host genome is made possible by these "sticky" ends. The identical "sticky ends" are generated when the plasmid is cut with the same restriction enzyme.
Protection against foreign genetic material, particularly bacteriophage DNA, is the major purpose of restriction endonucleases. These enzymes are also thought to be involved in transposition and recombination. Double-stranded DNA is split in half by restriction enzymes. The cut can have a sticky end or a blunt end, depending on the restriction enzyme. Because they guarantee that the human DNA fragment is put into the plasmid in the proper orientation, sticky ends are more beneficial in molecular cloning.
In light of this, we can say that these "sticky" ends to enable the insertion of "foreign" DNA into the host genome. The same "sticky ends" are created when slicing the plasmid with the same restriction enzyme.
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