describe the anatomical parts of the muscle triad and how the function of these organelles work together to initiate contraction.

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31-10-2022
Biology

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describe the anatomical parts of the muscle triad and how the function of these organelles work together to initiate contraction.

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tutorconsortium125 tutorconsortium125 · Answer 1 · 2022-11-03T02:32:00-04:00

The muscle triad consists of two adjacent SR terminal cisterns and one intervening T tubule. The T tubule is a cell membrane fold located between the sarcoplasmic reticuli.

what is muscle triad ?

The triad is a skeletal muscle substructure that regulates excitation-contraction coupling. It is formed by the T-tubule and the terminal sarcoplasmic reticulum coming together. A growing number of skeletal myopathies, known as triadopathies, are caused by gene mutations in triad components.

At their core, these disorders are caused by flaws in excitation contraction coupling and intracellular calcium homeostasis. Secondary triad structure and/or function abnormalities have been reported in several muscle diseases, most notably certain muscular dystrophies.

This review summarises current knowledge of both primary and secondary triadopathies and identifies key concepts that have yet to be fully addressed in the field. The review focuses on the pathogenesis of triadopathies as well as potential treatments.

Triads serve as the anatomical foundation for excitation-contraction coupling, which occurs when a stimulus excites the muscle and causes it to contract. A positively charged current is sent from the neuromuscular junction down the length of the T tubules, activating dihydropyridine receptors.

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