the progerin protein has a assume mw of 69.25 kda. where will the progerin band appear on the western blot, relative to the wild type (wt) lmna?

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31-10-2022
Biology

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the progerin protein has a assume mw of 69.25 kda. where will the progerin band appear on the western blot, relative to the wild type (wt) lmna?

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jaspreetsharma jaspreetsharma · Answer 1 · 2022-11-03T06:47:17-04:00

The LMNA gene, which codes for Lamins A and C, as well as the EMD gene, which codes for emerin, are the sites of the most common mutations associated with laminopathy symptoms.

Since the altered protein has a low molecular weight, it is transported more quickly. The laminopathy symptoms have numerous overlapping characteristics, which could indicate a disease spectrum rather than a collection of clinical entities that are wholly unique called as laminopathy symptoms.

The gene LMNA gene codes for proteins. Among the illnesses connected to LMNA gene are dilated cardiomyopathy and Hutchinson-Gilford progeria syndrome. Apoptosis, autophagy, and the mitotic cell cycle are some of its linked mechanisms.

Learn more about LMNA gene here

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