which oncologic emergency involves the failure in the negative feedback mechanism that normally regulates the release of antidiuretic hormone (adh)?

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28-10-2022
Biology

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which oncologic emergency involves the failure in the negative feedback mechanism that normally regulates the release of antidiuretic hormone (adh)?

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rathipushpendra345 rathipushpendra345 · Answer 1 · 2022-11-01T08:02:27-04:00

Syndrome of inappropriate antidiuretic hormone release (SIADH). Failure of the negative feedback mechanism, which ordinarily controls the release of antidiuretic hormone, results in SIADH (ADH).

DIC is a complicated coagulation and fibrinolysis condition that causes bleeding and thrombosis. The fast release of intracellular contents caused by the cell destruction brought on by radiation or chemotherapy in big or quickly progressing malignancies, such as leukemia, is known as tumor lysis syndrome. Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a medical disorder where the body produces an excessive amount of antidiuretic hormone (ADH). This hormone aids the kidneys in regulating how much water your body excretes in urine. The body retains too much water as a result of SIADH. Malignancy, pulmonary conditions, CNS diseases, and medications are the most frequent causes of SIADH. Bartter & Schwartz first identified SIADH in two patients with lung cancer who had severe hypo-natraemia at presentation.

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