When a carboxylate-containing compound linked to coenzyme A (such as acetate) is hydrolyzed, the resulting product has a higher free energy of hydrolysis than does a carboxylate-containing compound linked to an alcohol.
Free energy is the amount of energy needed to bring a molecule from its lowest-energy state to its highest-energy state. This property can be used to determine whether or not a molecule will break apart or remain intact under certain conditions.
In this example, if you added enough acetate to your reaction mixture, it would be more likely for the reactants to break apart because they have more free energy available in their reactant states.
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