suppose that for a certain gene, nearly 100 percent of the normal level of expression is required to produce the normal phenotype. what is the best prediction that you could make about mutation?

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26-10-2022
Biology

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suppose that for a certain gene, nearly 100 percent of the normal level of expression is required to produce the normal phenotype. what is the best prediction that you could make about mutation?

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qwrose qwrose · Answer 1 · 2022-10-28T10:05:58-04:00

Based on this requirement one could predict that a loss of function mutation would be dominant.

Phenotypic variation is an error that occurs during protein synthesis. These errors lead to amino acid substitutions that result in abnormal proteins. Experiments suggest that such errors are fairly common. We present a model for studying the effect of phenotypic mutation rate on the abundance of abnormal proteins in cells.

In our model, genes are regulated to synthesize a specific number of functional proteins. Depending on the phenotypic mutation rate, abnormal proteins are formed. Use data on protein length and abundance from Saccharomyces cerevisiae to parameterize the model.

Given the small rate of phenotypic variation, it is calculated that most aberrant proteins originate from highly expressed genes and, on average, are almost twice the average size of yeast proteins. Mutations can affect an organism by altering its physical properties (or phenotype) or affect how DNA encodes genetic information (genotype).

Learn more about Phenotypic mutations here:

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