during dna replication, the two strands of dna are pried apart and then serve as templates for synthesis of new strands. however, there are some big differences in how the two strands are copied. why is this so?

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26-10-2022
Biology

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during dna replication, the two strands of dna are pried apart and then serve as templates for synthesis of new strands. however, there are some big differences in how the two strands are copied. why is this so?

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rafikiedu08 rafikiedu08 · Answer 1 · 2022-10-29T05:45:23-04:00

Replication moves the replication point, also known as the replication fork, continuously from the origin to the terminal. The duplex of ds DNA is opened up during replication by an enzyme called Helicase, providing two templates for the production of new strands. These two strands are oriented differently; one runs in a 5'--3' direction, and the other in a 3'--5' way. The essential enzyme, DNA polymerase, is responsible for adding the complementary nucleotide while creating new DNA. Only nucleotides in the 5'--3' direction are added by DNA polymerase. Since DNA polymer flows in the same direction, one strand, in 5'--3', is continually produced. It is known as a leading strand. Another strand is in the 3'--5' direction, and here is where the issue lies. This strand was created in bits as the replication fork advanced. It is known as the lagging strand. The DNA ligase enzyme links these DNA pieces together.

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