An abrupt discontinuation of Sinemet can lead to neuroleptic malignant syndrome.
- Neuroleptic malignant syndrome (NMS) is a potentially fatal neurologic emergency caused by the use of antipsychotic (neuroleptic) medications. It is distinguished by a specific clinical presentation of mental status changes, stiffness, fever, and dysautonomia.
- Neuroleptic malignant syndrome symptoms typically include a high fever (102 to 104 degrees Fahrenheit), an irregular pulse, an accelerated heartbeat (tachycardia), an increased rate of respiration (tachypnea), muscle rigidity, altered mental status, and autonomic nervous system dysfunction resulting in high or low blood pressure.
- Neuroleptic malignant syndrome (NMS) is an uncommon and potentially fatal reaction to nearly any neuroleptic (antipsychotic) treatment. It is characterized by a high fever and muscle rigidity. Neuroleptic malignant syndrome (NMS) is a serious disorder induced by an unfavorable reaction to dopamine receptor antagonist drugs or the abrupt discontinuation of dopaminergic treatments.
Thus this is the meaning of neuroleptic malignant syndrome.
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